NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ
نویسندگان
چکیده
Florian R. Greten,1,4,* Melek C. Arkan,1,4 Julia Bollrath,1 Li-Chung Hsu,4 Jason Goode,4 Cornelius Miething,2 Serkan I. Göktuna,1 Michael Neuenhahn,3 Joshua Fierer,5 Stephan Paxian,1 Nico Van Rooijen,6 Yajun Xu,7 Timothy O’Cain,7 Bruce B. Jaffee,7 Dirk H. Busch,3 Justus Duyster,2 Roland M. Schmid,1 Lars Eckmann,5 and Michael Karin4,* 1Second Department of Medicine, Klinikum rechts der Isar 2Third Department of Medicine, Klinikum rechts der Isar 3Institute of Medical Microbiology, Immunology and Hygiene Technical University Munich, 81675 Germany 4Department of Pharmacology 5Department of Medicine University of California, San Diego, La Jolla, CA 92093, USA 6Vrije Universiteit, Vrije Universiteit Medical Center, 1007MB Amsterdam, Netherlands 7Millenium Pharmaceuticals, Cambridge, MA 02139, USA *Correspondence: [email protected] (F.R.G.), [email protected] (M.K.) DOI 10.1016/j.cell.2007.07.009
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ورودعنوان ژورنال:
- Cell
دوره 130 شماره
صفحات -
تاریخ انتشار 2007